I have been working with an interdisciplinary team to build and strengthen fragment-based discovery at Beryllium for ten years. I worked as the project lead on the effort to build our first in-house fragment screening collection, the metabolome-influenced “Fragments of Life.” This fragments collection has been deployed successfully in over a dozen proprietary discovery collaborations as well as several non-proprietary projects. My secondary research focus is in the area of nucleic acid structural biology. I was responsible for elucidating the three-dimensional structures of novel protein-nucleic acid complexes including Tn5 transposase, DNA Polymerase C and several protein:DNA aptamer complexes.
I am the lead crystallographer on more than 75 crystal structures deposited in the international Protein Data Bank and have published 30 peer-reviewed journal articles. I obtained a bachelor’s degree in biochemistry/biophysics from Washington State University and a doctorate in biochemistry from the University of Wisconsin-Madison. Structural biology is one of my passions. Even now, more than 20 years after I began my training in X-ray crystallography, I still get a rush when I discover a new crystal or when I see interesting electron density for the first time. I find that successful collaborations benefit from a focus on science against a backdrop of professional project management, and I look forward to a long future of discovery with our partners, clients and investors.