Services

Born in the USA, from leading Northwest structural biology labs Proximal to the largest and fastest growing engine for the research based drug discovery market on earth: Boston, MA

 

Beryllium’s model offers value innovation to the Preclinical Drug Discovery Market. With industry-leading flexibility working side-by-side as colleagues. We believe in de-risking the tricky business of research. You have a thesis. We make it easy and fast to “Pilot and Prove” that thesis with minimal upfront investment. Our research services model applies to a broad range of scientific partners. Fee-for-service contracts (project-based) or research collaborations (e.g. annualized, FTE-based)

gene-to-protein-structure-guided-lead-discovery

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Structure Determination

 

(NMR, X-Ray) See for yourself[/cws_sc_fa]

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Gene-to-Protein Production

Including complexes and membrane proteins.
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Gene to protein services boston and seattle USA

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Antibody:Antigen Characterization

Epitope mapping.
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Target Gallery

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Proteins in our Tagret Gallery

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Functional Biology

Cellular, Biochemical Assay.
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Fragment Screening

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Membrane Protein

Production, Screening and Structure
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Membrane Protein Engineering Services

Gene-to-Protein

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Protein Engineering and Production

We offer codon engineering at the nucleotide level based on research-derived algorithms using a variety of expression systems

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Antibody Antigen

[cws_sc_divider divi_style=’short’ height=’2′ border_style=’solid’ color=’#6ec6a9′ alignment=’left’ margin_top=’10’ margin_bottom=’30’]Unambiguously define your epitope-paratope interactions

  • Improve binding interactions using structural data
  • Obtain data imperative to strengthening patent applications

 

Accelerate the development of your antibody therapeutic programs

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Structural Biology

[cws_sc_divider divi_style=’short’ height=’2′ border_style=’solid’ color=’#6ec6a9′ alignment=’left’ margin_top=’10’ margin_bottom=’30’]Proven expertise in de novo structure determination:

  • Clear insight into Mechanism of Action
  • Validate targets, generate and optimize lead therapeutics
  • Structural insight to protein-protein, protein-ligand, and protein-nucleic acid interaction

 

Structure-guided solutions for your drug discovery programs

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Fragment Screening

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Efficiently sample target structure space

  • Smart pooled commercial and in-house libraries
  • High resolution NMR and X-ray crystallography platforms

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Smaller, more specific, fragments provide more efficient starting points for drug discovery than traditional HTS

Obtain small molecule start points for your drug discovery program

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Functional Biology

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  • Cell Biology
  • Biochemistry
  • Molecular Profiling
  • Content-rich, scalable, multiplexed platforms

 

Learn more about our Functional Biology Platforms

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Cell Engineering

  funbio-cell

REPORTER DESIGN / EXPRESSION

STABLE CELL LINE GENERATION

CLONE CHARACTERIZATION

Assay Development

  assay-development-service

HIGH CONTENT ANALYSIS

CELL-BASED AND CELL-FREE

BIOCHEMISTRY

Hit Confirmation & Validation

hit-confirmation-validation-service

MOLECULAR PROFILING

PATHWAYS ANALYSIS

DEEP PHENOTYPING

NMR facility for superior structural insights

NMR

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  • Low Sample Concentration Requirement
  • Rapid and Efficient Data Collection
  • High Field NMR Systems (700, 800) w/Cryoprobe

Unleash the power of our NMR facility for superior structural insights

 

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Membrane Protein Production

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  • Establish protocols and pipelines for expression and purification
  • Biophysical and biochemical characterization
  • Structural insight

 

Construct design, cell culture/fermentation, purification, crystallization

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Request a Quote

844-BE4-FOUR (844-234-3687)

info@be4.com

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