Services

Born in the USA, from leading Northwest structural biology labs Proximal to the largest and fastest growing engine for the research based drug discovery market on earth: Boston, MA

 

Beryllium’s model offers value innovation to the Preclinical Drug Discovery Market. With industry-leading flexibility working side-by-side as colleagues. We believe in de-risking the tricky business of research. You have a thesis. We make it easy and fast to “Pilot and Prove” that thesis with minimal upfront investment. Our research services model applies to a broad range of scientific partners. Fee-for-service contracts (project-based) or research collaborations (e.g. annualized, FTE-based)

gene-to-protein-structure-guided-lead-discovery

Structure Determination

 

(NMR, X-Ray) See for yourself

Gene-to-Protein Production

Including complexes and membrane proteins.
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Gene to protein services boston and seattle USA

Antibody:Antigen Characterization

Epitope mapping.
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Target Gallery

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Proteins in our Tagret Gallery

Functional Biology

Cellular, Biochemical Assay.
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Fragment Screening

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Membrane Protein

Production, Screening and Structure
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Membrane Protein Engineering Services

Gene-to-Protein

View Case Study for Protein Production

Protein Engineering and Production

We offer codon engineering at the nucleotide level based on research-derived algorithms using a variety of expression systems

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Antibody Antigen

Unambiguously define your epitope-paratope interactions

  • Improve binding interactions using structural data
  • Obtain data imperative to strengthening patent applications

 

Accelerate the development of your antibody therapeutic programs

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Structural Biology

Proven expertise in de novo structure determination:

  • Clear insight into Mechanism of Action
  • Validate targets, generate and optimize lead therapeutics
  • Structural insight to protein-protein, protein-ligand, and protein-nucleic acid interaction

 

Structure-guided solutions for your drug discovery programs

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Fragment Screening

Efficiently sample target structure space

  • Smart pooled commercial and in-house libraries
  • High resolution NMR and X-ray crystallography platforms

View Case Study for Fragment Screening

Smaller, more specific, fragments provide more efficient starting points for drug discovery than traditional HTS

Obtain small molecule start points for your drug discovery program

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900Structures deposited into the Protein Data Bank as part of the SSGCID structural genomics collaboration by Beryllium scientists.

1000proprietary structures delivered to clients covering many protein classes.

70Percent success rate for antibody-antigen complex with a mean resolution of 3.0 Å

90Percent success rate for humanized Fab structure with a mean resolution of 2.1 Å

Functional Biology

Maximize your data insights

  • Cell Biology
  • Biochemistry
  • Molecular Profiling
  • Content-rich, scalable, multiplexed platforms

 

Learn more about our Functional Biology Platforms

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Cell Engineering

  funbio-cell

REPORTER DESIGN / EXPRESSION

STABLE CELL LINE GENERATION

CLONE CHARACTERIZATION

Assay Development

  assay-development-service

HIGH CONTENT ANALYSIS

CELL-BASED AND CELL-FREE

BIOCHEMISTRY

Hit Confirmation & Validation

hit-confirmation-validation-service

MOLECULAR PROFILING

PATHWAYS ANALYSIS

DEEP PHENOTYPING

NMR facility for superior structural insights

NMR

Pharma-Grade Facilities and Expertise:

  • Low Sample Concentration Requirement
  • Rapid and Efficient Data Collection
  • High Field NMR Systems (700, 800) w/Cryoprobe

Unleash the power of our NMR facility for superior structural insights

 

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Membrane Protein Production

Production, Screening and Structure:

  • Establish protocols and pipelines for expression and purification
  • Biophysical and biochemical characterization
  • Structural insight

 

Construct design, cell culture/fermentation, purification, crystallization

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844-BE4-FOUR (844-234-3687)

info@be4.com

@2016 Beryllium Discovery Corp – 844-BE4-FOUR | info@be4.com

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