NMR

NMR Services

Pharma-Grade Facilities and Expertise:

  • Low Sample Concentration Requirement
  • Rapid and Efficient Data Collection
  • High Field NMR Systems (700, 800) w/Cryoprobe

Unleash the power of our NMR facility for superior structural insights

NMR facility for superior structural insights

700 MHz Bruker Avance III: 

  • Bruker 700 MHz ultra-shielded magnet
  • 3-channel console with z-axis gradients
  • High-sensitivity 1H/13C/15N-nuclei detection with HCN cryoprobe
  • High-throughput, temperature-controlled
  • SampleJet autosampler (5×96 samples)

500 MHz Varian Unity Inova

  • Oxford 500 MHz ultra-shielded magnet
  • 3-channel console with z-axis gradients
  • 1H/13C/15N-nuclei detection with HCN probe
  • 100 sample capacity (SMS autosampler)

 

NMR Pharma-Grade Facilities and Expertise

SCREENING

  • Target feasibility studies to optimize
    conditions and parameters
  • Screening of in-house and external libraries
  • NMR screening of smart pooled fragments
    with automated deconvolution
  • Hit validation and competition NMR screening
  • Ligand-observed methods (e.g. STD-NMR)
  • Protein observe methods (e.g. HSQC)

BIO-NMR
PROTEINS/
PEPTIDES/RNA/DNA

  • Complete NMR-based 3D structure determination
  • Sample optimization
  • Binding analysis and binding site identification
  • Resonance assignments
  • Isotopic labeling (uniform and selective)
  • SAR

SMALL MOLECULE

  • Structural analysis and determination
  • Binding affinity measurements
  • Stability analysis
  • Metabolite ID

Request a Quote

844-BE4-FOUR (844-234-3687)

info@be4.com

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